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KMID : 0043320080310050594
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.594 ~ p.597
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In Vitro Hepatoprotective Compounds from Suaeda glauca
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An Ren-Bo
Sohn Dong-Hwan
Jeong Gil-Saeng
Kim Youn-Chul
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Abstract
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Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O--D-galactoside (3), and quercetin 3-O--D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the values of and , respectively. Silybin as a positive control showed an value of .
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KEYWORD
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Suaeda glauca, Hepatoprotective, Methyl 3, 5-di-O-caffeoyl quinate, 3, 5-Di-O-caffeoyl quinic acid, Tacrine, Hep G2 cells, Chenopodiaceae
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